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Besides the aforementioned physical side effects, steroid use has also often been associated with a higher risk of depression and altered behavior among men, especially during periods of increased stress. In the past, physicians had little understanding of the possible psychological impact of hormone therapy. A new set of research findings shows a direct connection between the stress exposure hormone cortisol and the use of sex steroids. In a study from the journal Science Translational Medicine, researchers discovered that testosterone in particular is associated with increased levels of cortisol in the body, which is known to cause an increase in psychological and physiological stress. As a result, people taking testosterone are at higher risk for developing depression and psychological problems. To find out more about the study and their findings, I spoke to Professor Robert Buss, the co-director of Emory University's Division of Behavioral Pathology, and co-author of the study. The researchers conducted four studies involving more than 600 men. The first involved a longitudinal study in which they randomly assigned men to study either a placebo or low-dose testosterone. All men were then randomized to attend 12 weekly meetings over the next four months that focused on how they were coping with the stress and other symptoms common to the daily stresses of life. The second study involved a survey in which participants were asked about the frequency with which they used various forms of stress. The participants were asked about their level of psychological and physical anxiety as well as their use of anabolic androgenic steroids, which includes testosterone and its metabolites, like dihydrotestosterone. The third study involved a control group of about 200 men who were given placebo pills. Finally, the fourth study involved 40 randomly selected men who were given a placebo pill and then followed for four years from the fourth quarter of 2006 to the fourth quarter of 2011. All of the subjects also completed a psychometric assessment of their use of the stress management coping skills training, which measures stress management strategies. What researchers discovered was that in terms of mental health and stress management, the three groups did not differ significantly from one another. In fact, a significant increase in symptoms of depression and behavioral problems was observed among the low-dose and placebo men. Professor Buss explained that "These increases indicate that a particular subgroup of men who are at heightened risk for this kind of problem may respond to testosterone treatment with psychiatric problems." This is significant because most sex steroid users are male but are at high risk for developing a mental health problem since their hormone use interferes with the natural course of aging processes and can potentially worsen those problems Similar articles: